Wokshops

  • 1) Meeting of WG groups leaders (A. Mokhir - UHEI, I.O. Fritsky - TSNUK, Y. Voloshin – INEOS RAS, O. Varzatskii – IGIC NASU) hold in Kiev on 31 May 2012, where the directions in the design and synthesis of clatrochelate compounds were discussed. Additionally Prof. Mykola Slobodyanyk, head of inorganic chemistry department of TSNUK, took part in the discussion.
     
    2) Ukrainian-German workshop hold at TSNUK in Kiev on 14 June, 2012.
    During the workshop the TSNUK participants has focused on methods of growth of single crystalsof metal complexes and hybrid compounds (planned in WP1, Task 1.8) and the UHEI participants gave outlooks of their current research and various methods used for preparation and identification of the target compounds.
    The workshop was an opportunity for young researchers to present their methodological tools and data at international audience. Note, that it has been attended by a number of PhD students, students and staff members of TSNUK and IGIC NASU (the total number of participants was more than 30 persons).

    Workhop programme:
    1. Anna Pavlischuk, ESR, TSNUK “General overview on methods of growth of single crystals”.
    2. Sergei Malinkin, ESR, TSNUK “Methods of growth of single crystals of bi- and polynuclear complexes”.
    3. Turganbay Iskenderov, ER, TSNUK “XRD powder diffraction and random single crystals unit cell measurements as tools for proof of individuality of massive single crystals samples”.
    4. Irina Golenya, ER, TSNUK “Specifics of growth of single crystals of anionic and cationic complexes”.
    5. Stefania Tomyn, ESR, TSNUK “Preparation of single crystals of metal complexes with the help of hydrothermal synthesis”.
    6. Jenny Blechinger, ESR, UHEI, “Use of matrix-assisted laser desorption/ionization (MALDI) mass-spectrometry for the purposes of identification of small molecules and conjugates”.
    7. Misael Schleger, ESR, UHEI, “Methods of separation and purification of small molecules and bioconjugates using HPLC”.
    8. Gerrit Rebmann, ESR, UHEI, “UV/Vis and fluorescence spectroscopy for the detection of bioconjugates and biomolecules”.
    9.  Paul D. Marzenell, ESR, UHEI, “Synthesis of bioconjugates of small molecules and nucleic acids and their antisense activity”.
    10. Helen Hagen, ESR, UHEI, “Cytotoxicity, cell-membrane permeability & biological activity of small molecules”.

    3) A workshop on “Experimental methods of single crystal structure determination and computer methods for crystal structure solution and refinement” hold at IGIC NASU on 12.03.2013.
    During the workshop the INEOS and TSNUK participants has focused on methods of crystal structure determination, solution and refinementof metal complexes and hybrid compounds (planned in WP2, Task 3.8) and the UHEI, UWR and INEOS participants gave outlooks of their current research and various methods used for the preparation and identification of the target compounds.
    The workshop was an opportunity for young researchers to present their methodological tools and data at international audience. Note, that it has been attended by a number of PhD students, students and staff members of TSNUK and IGIC NASU (the total number of participants was more than 20 persons).

    Workhop programme:
    1. Igor O. Fritsky, ER, TSNUK “General overview on methods of single crystals structure solution”.
    2. Oleg Varzatskii, ER, IGIC “Methods of single crystal structure refinement”.
    3. Turganbay Iskenderov, ER, TSNUK “Methods of absorption correction in the course of sigle crystal structure solution and refinement”.
    4. Stefania Tomyn, ESR, TSNUK “Perchlorate disorder: a common problem for crystal structures of cations complexes. How to cope with perchlorate disorder.”
    5. Viktor Chernii, ER, IGIC “Crystal structures of hybride metal complexes featuring clathrochelate and phtalocyanine moieties”.
    6. Yan Z. Voloshin, ER, INEOS “Regularities in single crystal structures of lacunar chlathrochelates”.
    7. Nina Chornenka, ESR, INEOS  “Study of crystal structures of metal complexes at various temperatures”.
    8. Iryna Denisenko, ESR, INEOS “Localization and treatment of hydrogen atoms in the course of single crystal structure refimenent”.
    9. Olexii Zozulia, ESR, FAU "Development of cleavable chemical fragments for regulation of biochemical processes".
    10. Agnieszka Szebesczyk, ESR, UWR “Mass spectrometry - theoretical foundations and possibilities of application in the analysis of cage compounds”.

    4) FP7-PEOPLE-2011-IRSES Workshop on Design and elaboration of novel topological drugs based on cage compounds “CAGEDRUGS”, 29.08.2013, hold on Wroclaw during the XII International Symposium on Inorganic Biochemistry: Collaboration and Beyond, 28 August - 1 September 2013, Wroclaw, Poland.
    During the workshop the participants has focused on methods of synthesis, structural study, identification and physico-chemical characterization as well as biological study of metal cage complexes and hybrid compounds.
    The workshop was an opportunity for the participating researchers to present their results at international audience. Note, that it has been attended by a number of the Symposium participants not involved in the current project (the total number of participants was more than 40 persons). The ESR from the participating groups had an opportunity to present their results obtained in the framework of the current project as posters during the poster sessions of the XII International Symposium on Inorganic Biochemistry.
     
    Workhop programme:
    1. Yan Z. Voloshin, ER, INEOS “Functionalized rhenium(III) semi-clathrochelates as prototypes of the 99m-technecium-containing radiopharmaceuticals”
    2. Igor O. Fritsky, ER, TSNUK “Template Synthesis, Structure and Properties of 3d-metals Clatrochelates Based on Hydrazide Ligands”
    3. Vladyslava B. Kovalska, ER, INEOS “Binding of the functionalized closo-borates to albumins: a protein fluorescence quenching study”
    4. Agnieszka Szebesczyk, ESR, UWR “The use of physico-chemical methods in the analysis of cage compounds”

    5) Meeting of WG group’s leaders.
    Two meetings of WG group’s leaders were hold in Kiev: on April 29, 2014 (E. Gumienna-Kontecka - UWR, I.O. Fritsky - TSNUK, O. Varzatskii – IGIC NASU) and May 28, 2014  (E. Gumienna-Kontecka - UWR, I.O. Fritsky - TSNUK, and O. Varzatskii – IGIC NASU, H. Kozlowski - UWR, the project scientist). The project leaders have discussed the project’s progress, its achievements and problems. Also the directions in the methods of physico-chemical and biological study of clatrochelate compounds were discussed.

    6) Ukrainian-Polish workshop hold at TSNUK in Kiev on May 28, 2014.
    During the workshop the UWR and TSNUK representatives presented current research areas and ideas for the development of CAGEDRUGS project. Particularly, this workshop covered topics envisaged by the workshop on “Computer modeling of polynuclear complex formation processes in solution and their speciation” (Task 4.7).
    The workshop was an opportunity for young researchers to present their methodological tools and data at international audience. The workshop has been attended by a number of undergraduate and PhD students, and staff members of TSNUK and IGIC NASU (the total number of participants was around 35).
     
    Workhop programme:
    1. Henryk Kozlowski, ER, UWR “Role of poly-Histidine tags in metal ion binding”.
    2. Elzbieta Gumienna-Kontecka, ER, UWR “Can we deceive bacteria with ferrichrome biomimetic analogs?”.
    3. Karolina Krzywoszynska, ESR, UWR "Polythiol binding to biologically relevant metal ions".
    4. Illia Guralskyi, ER, TSNUK “Spin crossover actuators”.
    5. Viktor Reshetnikov, ESR, TSNUK “Macrocyclic stabilization of Copper(III) Ions”.
    6. Stefania Tomyn, ESR, TSNUK “Synthesis and investigation of clathrochelate complexes of 3d-metals”
    7. Anna Pavlischuk, ESR, TSNUK “Structures and properties of systems based on 15-MC-5 blocks”.

     

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